Interações medicamentosas
Bcg vaccine live + Sirolimus
Gravidade: Contraindicada
Bcg vaccine live and Sirolimus: contraindicated interaction.
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Resumo
Sirolimus suppresses immune responses, so a live BCG vaccine may fail to produce protection and may cause disseminated BCG infection. Live vaccines are generally avoided in patients on immunosuppressive therapy.
O que esta interação significa em palavras simples
Bcg vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Sirolimus-mediated immunosuppression allows uncontrolled replication of the live attenuated organism and blunts the vaccine response.
O que fazer
Do not give live BCG vaccine during sirolimus therapy. Vaccinate before starting immunosuppression where feasible.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicada
- Ketoconazole + Sirolimus Contraindicada
- Levoketoconazole + Sirolimus Contraindicada
- Measles mumps and rubella vaccine live + Sirolimus Contraindicada
- Measles mumps and rubella vaccine + Sirolimus Contraindicada
Perguntas frequentes
Can I take Bcg vaccine live with Sirolimus?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sirolimus suppresses immune responses, so a live BCG vaccine may fail to produce protection and may cause disseminated BCG infection. Live vaccines are generally avoided in patients on immunosuppressive therapy.
How serious is the interaction between Bcg vaccine live and Sirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live BCG vaccine during sirolimus therapy. Vaccinate before starting immunosuppression where feasible.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Ketoconazole. The full list is on the Sirolimus page.
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