Interações medicamentosas
Lincomycin + Rapacuronium
Gravidade: Grave
Lincomycin and Rapacuronium: major interaction.
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Resumo
Lincosamide antibiotics have intrinsic neuromuscular blocking activity and can potentiate non-depolarizing blockers. This may prolong paralysis and delay recovery of respiratory function.
O que esta interação significa em palavras simples
Lincomycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive neuromuscular blockade through presynaptic and postsynaptic effects of lincomycin.
O que fazer
Monitor neuromuscular function with a nerve stimulator and maintain ventilatory support until full recovery. Reduce the neuromuscular blocker dose if needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Lincomycin
- Atracurium + Lincomycin Grave
- Cisatracurium + Lincomycin Grave
- Lincomycin + Pancuronium Grave
- Lincomycin + Rocuronium Grave
- Lincomycin + Vecuronium Grave
- Cholera vaccine + Lincomycin Moderada
Perguntas frequentes
Can I take Lincomycin with Rapacuronium?
MediHelp rates the interaction as major. Lincomycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lincosamide antibiotics have intrinsic neuromuscular blocking activity and can potentiate non-depolarizing blockers. This may prolong paralysis and delay recovery of respiratory function.
How serious is the interaction between Lincomycin and Rapacuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and maintain ventilatory support until full recovery. Reduce the neuromuscular blocker dose if needed.
What other medicines interact with Lincomycin?
MediHelp also lists interactions of Lincomycin with, for example, Atracurium, Cisatracurium, Pancuronium. The full list is on the Lincomycin page.
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