Interações medicamentosas
Lincomycin + Vecuronium
Gravidade: Grave
Lincomycin and Vecuronium: major interaction.
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Resumo
Lincosamides can potentiate non-depolarising muscle relaxants and prolong neuromuscular blockade. Reports describe delayed recovery and respiratory depression after combined use.
O que esta interação significa em palavras simples
Lincomycin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lincomycin belongs to Anti Bacterial; Vecuronium belongs to Musculoskeletal.
Por que acontece
Lincomycin has weak intrinsic neuromuscular blocking activity acting at pre- and postsynaptic sites, adding to vecuronium's effect.
O que fazer
Monitor neuromuscular function with a train-of-four monitor and titrate vecuronium to effect. Ensure ventilatory support until recovery is complete, or choose a different antibiotic.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Vecuronium
Outras interações de Lincomycin
- Atracurium + Lincomycin Grave
- Cisatracurium + Lincomycin Grave
- Lincomycin + Pancuronium Grave
- Lincomycin + Rapacuronium Grave
- Lincomycin + Rocuronium Grave
- Cholera vaccine + Lincomycin Moderada
Perguntas frequentes
Can I take Lincomycin with Vecuronium?
MediHelp rates the interaction as major. Lincomycin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lincosamides can potentiate non-depolarising muscle relaxants and prolong neuromuscular blockade. Reports describe delayed recovery and respiratory depression after combined use.
How serious is the interaction between Lincomycin and Vecuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a train-of-four monitor and titrate vecuronium to effect. Ensure ventilatory support until recovery is complete, or choose a different antibiotic.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
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