Interações medicamentosas
Megestrol + Warfarin
Gravidade: Moderada
Megestrol and Warfarin: moderate interaction.
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Resumo
Increases in INR and bleeding have been reported in patients on warfarin who start megestrol. The reports are limited, and the effect varies between patients.
O que esta interação significa em palavras simples
Megestrol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Megestrol belongs to Oncology; Warfarin belongs to Cardiovascular.
Por que acontece
The mechanism is not established; altered warfarin metabolism or protein binding has been proposed.
O que fazer
Check INR within a week of starting or stopping megestrol and adjust the warfarin dose accordingly.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Warfarin
- Defibrotide + Warfarin Contraindicada
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Outras interações de Megestrol
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- Insulin degludec-liraglutide + Megestrol Moderada
- Insulin degludec + Megestrol Moderada
- Insulin inhaled + Megestrol Moderada
Perguntas frequentes
Can I take Megestrol with Warfarin?
MediHelp rates the interaction as moderate. Megestrol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Increases in INR and bleeding have been reported in patients on warfarin who start megestrol. The reports are limited, and the effect varies between patients.
How serious is the interaction between Megestrol and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a week of starting or stopping megestrol and adjust the warfarin dose accordingly.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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