Interações medicamentosas
Mifepristone + Prednisolone
Gravidade: Contraindicada
Mifepristone and Prednisolone: contraindicated interaction.
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Resumo
Mifepristone antagonizes glucocorticoid receptors and can reduce the effect of corticosteroids. In patients on long-term steroid treatment this may cause adrenal insufficiency or loss of disease control, and labeling lists chronic corticosteroid therapy as a contraindication.
O que esta interação significa em palavras simples
Mifepristone and Prednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mifepristone belongs to Endocrine; Prednisolone belongs to Endocrine.
Por que acontece
Mifepristone blocks glucocorticoid receptors, opposing the effect of prednisolone.
O que fazer
Do not use mifepristone in patients on long-term corticosteroid therapy. Seek specialist advice if both are needed, as standard steroid doses may be ineffective.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Prednisolone
- Bcg vaccine live + Prednisolone Contraindicada
- Measles mumps and rubella vaccine live + Prednisolone Contraindicada
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicada
- Measles vaccine + Prednisolone Contraindicada
- Prednisolone + Radium-223 dichloride Contraindicada
- Prednisolone + Rubella vaccine Contraindicada
Outras interações de Mifepristone
- Apixaban + Mifepristone Contraindicada
- Argatroban + Mifepristone Contraindicada
- Cisapride + Mifepristone Contraindicada
- Cortisone + Mifepristone Contraindicada
- Cyclosporin + Mifepristone Contraindicada
- Dabigatran etexilate + Mifepristone Contraindicada
Perguntas frequentes
Can I take Mifepristone with Prednisolone?
MediHelp rates the interaction as contraindicated. Mifepristone and Prednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone antagonizes glucocorticoid receptors and can reduce the effect of corticosteroids. In patients on long-term steroid treatment this may cause adrenal insufficiency or loss of disease control, and labeling lists chronic corticosteroid therapy as a contraindication.
How serious is the interaction between Mifepristone and Prednisolone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use mifepristone in patients on long-term corticosteroid therapy. Seek specialist advice if both are needed, as standard steroid doses may be ineffective.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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