Interações medicamentosas
Mitoxantrone + Trastuzumab
Gravidade: Grave
Mitoxantrone and Trastuzumab: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Trastuzumab combined with an anthracenedione such as mitoxantrone increases the risk of heart failure and reduced left ventricular ejection fraction. Neutropenia may also be more frequent when trastuzumab is added to myelosuppressive chemotherapy.
O que esta interação significa em palavras simples
Mitoxantrone and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitoxantrone belongs to Central Nervous System; Trastuzumab belongs to Oncology.
Por que acontece
Additive cardiotoxicity from HER2 inhibition of cardiomyocyte survival signalling combined with mitoxantrone's direct myocardial damage; additive myelosuppression also contributes.
O que fazer
Avoid concurrent use where possible. Assess LVEF before and periodically during therapy and monitor neutrophil counts.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Mitoxantrone
Outras interações de Trastuzumab
Perguntas frequentes
Can I take Mitoxantrone with Trastuzumab?
MediHelp rates the interaction as major. Mitoxantrone and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab combined with an anthracenedione such as mitoxantrone increases the risk of heart failure and reduced left ventricular ejection fraction. Neutropenia may also be more frequent when trastuzumab is added to myelosuppressive chemotherapy.
How serious is the interaction between Mitoxantrone and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. Assess LVEF before and periodically during therapy and monitor neutrophil counts.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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