Interações medicamentosas
Liposomal doxorubicin + Trastuzumab
Gravidade: Grave
Liposomal doxorubicin and Trastuzumab: major interaction.
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Resumo
Trastuzumab can cause cardiomyopathy and left ventricular dysfunction, and the risk is markedly higher when it follows or is combined with anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin, but additive cardiac injury remains a concern.
O que esta interação significa em palavras simples
Liposomal doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Liposomal doxorubicin belongs to Oncology; Trastuzumab belongs to Oncology.
Por que acontece
Additive cardiotoxicity: anthracycline myocyte injury combined with HER2 pathway inhibition impairing cardiomyocyte repair.
O que fazer
Assess LVEF before and periodically during therapy, and avoid concurrent use outside carefully monitored settings. Hold trastuzumab or stop the anthracycline if LVEF falls significantly or heart failure symptoms appear.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicada
- Belatacept + Liposomal doxorubicin Grave
- Cyclosporine + Liposomal doxorubicin Grave
- Dronedarone + Liposomal doxorubicin Grave
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Grave
- Fingolimod + Liposomal doxorubicin Grave
Outras interações de Trastuzumab
Perguntas frequentes
Can I take Liposomal doxorubicin with Trastuzumab?
MediHelp rates the interaction as major. Liposomal doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab can cause cardiomyopathy and left ventricular dysfunction, and the risk is markedly higher when it follows or is combined with anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin, but additive cardiac injury remains a concern.
How serious is the interaction between Liposomal doxorubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess LVEF before and periodically during therapy, and avoid concurrent use outside carefully monitored settings. Hold trastuzumab or stop the anthracycline if LVEF falls significantly or heart failure symptoms appear.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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