Interações medicamentosas
Daunorubicin + Trastuzumab
Gravidade: Grave
Daunorubicin and Trastuzumab: major interaction.
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Resumo
Trastuzumab causes cardiac dysfunction, and anthracyclines such as daunorubicin cause cumulative dose-related cardiomyopathy. Used together or in close sequence, the risk of symptomatic heart failure and reduced ejection fraction is clearly higher than with either drug alone.
O que esta interação significa em palavras simples
Daunorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daunorubicin belongs to Oncology; Trastuzumab belongs to Oncology.
Por que acontece
Additive cardiotoxicity: anthracycline myocyte injury combined with impaired HER2-dependent cardiomyocyte survival signaling.
O que fazer
Avoid concurrent use where possible and keep a long interval between anthracycline and trastuzumab. Assess LVEF before and regularly during treatment, and stop trastuzumab if significant decline occurs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicada
- Belatacept + Daunorubicin Grave
- Cyclosporine + Daunorubicin Grave
- Cyclosporin + Daunorubicin Grave
- Daunorubicin + Dengue vaccine Grave
- Daunorubicin + Etrasimod Grave
Outras interações de Trastuzumab
Perguntas frequentes
Can I take Daunorubicin with Trastuzumab?
MediHelp rates the interaction as major. Daunorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab causes cardiac dysfunction, and anthracyclines such as daunorubicin cause cumulative dose-related cardiomyopathy. Used together or in close sequence, the risk of symptomatic heart failure and reduced ejection fraction is clearly higher than with either drug alone.
How serious is the interaction between Daunorubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and keep a long interval between anthracycline and trastuzumab. Assess LVEF before and regularly during treatment, and stop trastuzumab if significant decline occurs.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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