Interações medicamentosas
Epirubicin + Trastuzumab
Gravidade: Grave
Epirubicin and Trastuzumab: major interaction.
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Resumo
Concurrent or sequential use of trastuzumab with anthracyclines such as epirubicin increases the incidence and severity of cardiomyopathy. Heart failure may develop and be clinically significant.
O que esta interação significa em palavras simples
Epirubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Epirubicin belongs to Oncology; Trastuzumab belongs to Oncology.
Por que acontece
Additive cardiotoxicity from anthracycline injury and HER2 pathway inhibition.
O que fazer
Avoid concurrent use outside protocols with strict cardiac surveillance. Check LVEF at baseline and periodically, and hold therapy if LVEF declines significantly.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Epirubicin
- Adenovirus types 4 and 7 live + Epirubicin Contraindicada
- Belatacept + Epirubicin Grave
- Cimetidine + Epirubicin Grave
- Deferiprone + Epirubicin Grave
- Dengue vaccine + Epirubicin Grave
- Epirubicin + Etrasimod Grave
Outras interações de Trastuzumab
Perguntas frequentes
Can I take Epirubicin with Trastuzumab?
MediHelp rates the interaction as major. Epirubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent or sequential use of trastuzumab with anthracyclines such as epirubicin increases the incidence and severity of cardiomyopathy. Heart failure may develop and be clinically significant.
How serious is the interaction between Epirubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use outside protocols with strict cardiac surveillance. Check LVEF at baseline and periodically, and hold therapy if LVEF declines significantly.
What other medicines interact with Epirubicin?
MediHelp also lists interactions of Epirubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cimetidine. The full list is on the Epirubicin page.
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