Interações medicamentosas
Phenytoin + Roflumilast
Gravidade: Grave
Phenytoin and Roflumilast: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Phenytoin is a strong inducer of CYP enzymes and can substantially lower roflumilast and active metabolite exposure. Roflumilast labeling advises against use with strong inducers because efficacy may be lost.
O que esta interação significa em palavras simples
Phenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Phenytoin belongs to Central Nervous System; Roflumilast belongs to Respiratory.
Por que acontece
Induction of CYP3A4 and CYP1A2 by phenytoin increases roflumilast metabolism.
O que fazer
Avoid the combination and consider an alternative COPD therapy. If both are continued, monitor exacerbation frequency closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
- Roflumilast - FDA drug label (DailyMed) — openFDA / DailyMed
Outras interações de Roflumilast
Outras interações de Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicada
- Bictegravir + Phenytoin Contraindicada
- Cabotegravir + Phenytoin Contraindicada
- Doravirine + Phenytoin Contraindicada
- Elbasvir / grazoprevir + Phenytoin Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicada
Perguntas frequentes
Can I take Phenytoin with Roflumilast?
MediHelp rates the interaction as major. Phenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin is a strong inducer of CYP enzymes and can substantially lower roflumilast and active metabolite exposure. Roflumilast labeling advises against use with strong inducers because efficacy may be lost.
How serious is the interaction between Phenytoin and Roflumilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative COPD therapy. If both are continued, monitor exacerbation frequency closely.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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