Лекарственные взаимодействия
Ethinyl estradiol-drospirenone + Lamotrigine
Тяжесть: Тяжёлое
Ethinyl estradiol-drospirenone and Lamotrigine: major interaction.
Последнее обновление
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Кратко
Ethinyl estradiol-containing contraceptives substantially lower lamotrigine concentrations, which may lead to loss of seizure or mood control. Lamotrigine levels rise during the pill-free week, which may cause toxicity such as dizziness, diplopia and ataxia.
Что означает это взаимодействие простыми словами
Ethinyl estradiol-drospirenone and Lamotrigine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-drospirenone belongs to Endocrine; Lamotrigine belongs to Central Nervous System.
Почему это происходит
Ethinyl estradiol induces UGT-mediated glucuronidation of lamotrigine, increasing its clearance.
Что делать
Monitor clinical response and lamotrigine levels when starting or stopping the contraceptive, and adjust the lamotrigine dose as needed. Consider continuous active-pill use to limit fluctuations during the pill-free week.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Другие взаимодействия Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Противопоказано
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Противопоказано
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Противопоказано
- Ethinyl estradiol-drospirenone + Tranexamic acid Противопоказано
- Aminocaproic acid + Ethinyl estradiol-drospirenone Тяжёлое
- Amobarbital + Ethinyl estradiol-drospirenone Тяжёлое
Другие взаимодействия Lamotrigine
Частые вопросы
Can I take Ethinyl estradiol-drospirenone with Lamotrigine?
MediHelp rates the interaction as major. Ethinyl estradiol-drospirenone and Lamotrigine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethinyl estradiol-containing contraceptives substantially lower lamotrigine concentrations, which may lead to loss of seizure or mood control. Lamotrigine levels rise during the pill-free week, which may cause toxicity such as dizziness, diplopia and ataxia.
How serious is the interaction between Ethinyl estradiol-drospirenone and Lamotrigine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and lamotrigine levels when starting or stopping the contraceptive, and adjust the lamotrigine dose as needed. Consider continuous active-pill use to limit fluctuations during the pill-free week.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
