Drug interactions
Ozanimod + Safinamide
Severity: Contraindicated
Ozanimod and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
What this interaction means in plain words
Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
MAO-B inhibition alters formation of ozanimod's active metabolites, which may also inhibit MAO, creating a risk of excess adrenergic stimulation.
What to do
Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ozanimod with Safinamide?
MediHelp rates the interaction as contraindicated. Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
How serious is the interaction between Ozanimod and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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