藥品參考
Elacestrant
Elacestrant is a medicine in the class oncology. It is used for breast cancer.
- 藥物類別: Oncology
- 用途: breast cancer
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- 常見劑型
- 錠劑
- 已知交互作用
- 50 (嚴重: 20 · 中度: 23 · 輕微: 7)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Elacestrant is an estrogen receptor antagonist that binds to ERα and inhibits estradiol-mediated proliferation of ER+ HER2- breast cancer cells, with degradation of ERα protein via the proteasomal pathway.
成人常用劑量（仿單摘要）
ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer: 345 mg orally with food once daily until disease progression or unacceptable toxicity
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: in rats it caused embryo-fetal death and limb and skull malformations below human exposure; no human data. Verify pregnancy status first. Women, and men with female partners, should use effective contraception during treatment and for 1 week after.
- 哺乳
- Unsafe No data on milk levels. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
已通報的副作用
- Musculoskeletal pain
- Nausea
- Increased cholesterol
- Increased AST
- Increased triglycerides
- Fatigue
哪些人需要特別留意
- Dyslipidemia: hypercholesterolemia and hypertriglyceridemia may occur; monitor lipid profile before starting and periodically.
- Embryo-fetal toxicity: can cause fetal harm; advise effective contraception during treatment and for 1 week after the last dose.
- May impair fertility in females and males of reproductive potential.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (50)
- Amobarbital + Elacestrant Major
- Apalutamide + Elacestrant Major
- Aprepitant + Elacestrant Major
- Armodafinil + Elacestrant Major
- Carbamazepine + Elacestrant Major
- Clarithromycin + Elacestrant Major
- Efavirenz + Elacestrant Major
- Elacestrant + Enzalutamide Major
- Elacestrant + Erythromycin Major
- Elacestrant + Eslicarbazepine Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Elacestrant 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Elacestrant used for?
Elacestrant is a medicine in the class oncology. It is used for Breast cancer.
What side effects have been reported with Elacestrant?
Musculoskeletal pain, Nausea, Increased cholesterol, Increased AST, Increased triglycerides, Fatigue.
Can Elacestrant be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in rats it caused embryo-fetal death and limb and skull malformations below human exposure; no human data. Verify pregnancy status first. Women, and men with female partners, should use effective contraception during treatment and for 1 week after. Breastfeeding: Unsafe. No data on milk levels. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
What does Elacestrant interact with?
MediHelp lists 50 known interactions for Elacestrant. Major: 20 · Moderate: 23 · Minor: 7. The most serious include Amobarbital, Apalutamide, Aprepitant.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
