藥物交互作用
Elacestrant + Eslicarbazepine
嚴重程度: 嚴重
Elacestrant and Eslicarbazepine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Elacestrant is a CYP3A4 substrate, and inducers reduce its exposure. Eslicarbazepine may therefore decrease its efficacy in breast cancer.
用白話說明這項交互作用的意義
Elacestrant and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Eslicarbazepine belongs to Central Nervous System.
為什麼會發生
CYP3A4 induction by eslicarbazepine increases elacestrant clearance.
處置方式
Avoid combination where possible by using a non-inducing antiseizure drug; labeling advises avoiding strong and moderate CYP3A inducers.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Eslicarbazepine 的其他交互作用
Elacestrant 的其他交互作用
常見問題
Can I take Elacestrant with Eslicarbazepine?
MediHelp rates the interaction as major. Elacestrant and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Elacestrant is a CYP3A4 substrate, and inducers reduce its exposure. Eslicarbazepine may therefore decrease its efficacy in breast cancer.
How serious is the interaction between Elacestrant and Eslicarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible by using a non-inducing antiseizure drug; labeling advises avoiding strong and moderate CYP3A inducers.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
