藥物交互作用
Elacestrant + Erythromycin
嚴重程度: 嚴重
Elacestrant and Erythromycin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Erythromycin, a moderate CYP3A4 inhibitor, can raise elacestrant concentrations and increase its adverse effects. Labeling advises avoiding moderate CYP3A4 inhibitors with elacestrant.
用白話說明這項交互作用的意義
Elacestrant and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Erythromycin belongs to Anti Bacterial.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of elacestrant increases its exposure.
處置方式
Avoid concomitant use and choose a non-CYP3A4-inhibiting antibiotic such as azithromycin or doxycycline where appropriate. If unavoidable, monitor for elacestrant adverse effects such as nausea and hepatic enzyme changes.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Erythromycin 的其他交互作用
Elacestrant 的其他交互作用
常見問題
Can I take Elacestrant with Erythromycin?
MediHelp rates the interaction as major. Elacestrant and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin, a moderate CYP3A4 inhibitor, can raise elacestrant concentrations and increase its adverse effects. Labeling advises avoiding moderate CYP3A4 inhibitors with elacestrant.
How serious is the interaction between Elacestrant and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose a non-CYP3A4-inhibiting antibiotic such as azithromycin or doxycycline where appropriate. If unavoidable, monitor for elacestrant adverse effects such as nausea and hepatic enzyme changes.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
