藥品參考
Galcanezumab
Galcanezumab is a medicine in the class central nervous system. It is used for cluster headache.
- 藥物類別: Central Nervous System
- 用途: cluster headache
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
- 常見劑型
- 注射劑
- 常見規格
- 120 mg/ml, 100 mg/ml
- 已知交互作用
- 3 (中度: 3)
- 商品名
- 5
- 國家與市場
- 5
用途
作用方式
Humanized monoclonal antibody; binds to calcitonin gene-related peptide (CGRP) ligand and blocks its binding to the receptor
成人常用劑量（仿單摘要）
Migraine Prophylaxis: Loading dose: 240 mg SC once (ie, 2 consecutive 120-mg SC injections), Maintenance dose: 120 mg SC monthly
懷孕與哺乳
- 懷孕
- Unknown No adequate human data; no harm in rat and rabbit studies. As an IgG antibody it crosses the placenta, mainly late in pregnancy, and exposure continues for months after the last dose; a pregnancy registry exists. EU label: as a precaution, preferable to avoid in pregnancy.
- 哺乳
- Unknown No milk data. EU label: a risk cannot be excluded in the first days after birth; afterwards use only if clinically needed. LactMed: likely very low in milk and partly digested by the infant; use with caution, especially with a newborn or preterm infant.
已通報的副作用
- Injection site reactions
- Angioedema
禁忌症
- Serious hypersensitivity to galcanezumab-gnlm or to any of the excipients.
哪些人需要特別留意
- Hypersensitivity reactions (dyspnea, urticaria, rash; anaphylaxis and angioedema postmarketing) can occur, even days after administration, and may be prolonged. If a serious reaction occurs, discontinue and treat appropriately.
- Constipation with serious complications, including hospitalization and surgery, has been reported, usually after the first dose. Monitor for severe constipation; medications that reduce GI motility may increase the risk.
- New-onset or worsening hypertension has been reported, most often within 7 days of starting. Monitor blood pressure and consider discontinuation if no other cause is found or BP is inadequately controlled.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (3)
- Efgartigimod / hyaluronidase sc + Galcanezumab Moderate
- Efgartigimod alfa + Galcanezumab Moderate
- Galcanezumab + Rozanolixizumab Moderate
同類別的其他藥品
常見問題
What is Galcanezumab used for?
Galcanezumab is a medicine in the class central nervous system. It is used for Cluster headache, Migraine.
What side effects have been reported with Galcanezumab?
Injection site reactions, Angioedema.
Can Galcanezumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data; no harm in rat and rabbit studies. As an IgG antibody it crosses the placenta, mainly late in pregnancy, and exposure continues for months after the last dose; a pregnancy registry exists. EU label: as a precaution, preferable to avoid in pregnancy. Breastfeeding: Unknown. No milk data. EU label: a risk cannot be excluded in the first days after birth; afterwards use only if clinically needed. LactMed: likely very low in milk and partly digested by the infant; use with caution, especially with a newborn or preterm infant.
What does Galcanezumab interact with?
MediHelp lists 3 known interactions for Galcanezumab. Moderate: 3. The most serious include Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Rozanolixizumab.
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