藥品參考
Ivacaftor
Ivacaftor is a medicine in the class miscellaneous. It is used for cystic fibrosis.
- 藥物類別: Miscellaneous
- 用途: cystic fibrosis
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- ATC 代碼
- R07AX02
- 常見劑型
- 錠劑
- 常見規格
- 150 mg
- 已知交互作用
- 119 (禁忌併用: 1 · 嚴重: 10 · 中度: 51 · 輕微: 57)
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
Ivacaftor is a CFTR potentiator that increases chloride transport by increasing the channel open probability (gating) of CFTR protein at the cell surface.
成人常用劑量（仿單摘要）
Cystic fibrosis (adults and patients aged 6 years and older): 150 mg orally every 12 hours (300 mg total daily dose) with fat-containing food
懷孕與哺乳
- 懷孕
- Unknown Limited human data (under 300 pregnancies); no harm in rats or rabbits at 5 to 11 times human exposure. EU label: as a precaution, preferable to avoid. Stopping may worsen cystic fibrosis, and CF teams often continue it, so decide with the CF specialist.
- 哺乳
- Safe Low milk levels and very low infant blood levels; no infant harm reported, and expert groups consider it probably safe. EU label: weigh benefits. LactMed: check the infant's liver tests and eyes (cataracts) periodically, and test for CF, as it can mask it.
已通報的副作用
- Headache
- Upper respiratory tract infection
- Nasal congestion
- Nausea
- Rash
- Oropharyngeal pain
哪些人需要特別留意
- Elevated transaminases: assess ALT/AST before starting, every 3 months in first year, then annually; interrupt dosing if ALT or AST greater than 5 times ULN.
- Hypersensitivity reactions including anaphylaxis reported postmarketing; discontinue and treat if serious signs develop.
- Intracranial hypertension reported with similar active ingredients; interrupt and refer if unusual headache or visual disturbances occur.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (119)
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
- Ivacaftor + Oxcarbazepine Major
- Ivacaftor + Phenobarbitone Major
- Ivacaftor + Phenytoin Major
- Ivacaftor + Rifabutin Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Ivacaftor 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
常見問題
What is Ivacaftor used for?
Ivacaftor is a medicine in the class miscellaneous. It is used for Cystic fibrosis.
What side effects have been reported with Ivacaftor?
Headache, Upper respiratory tract infection, Nasal congestion, Nausea, Rash, Oropharyngeal pain.
Can Ivacaftor be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data (under 300 pregnancies); no harm in rats or rabbits at 5 to 11 times human exposure. EU label: as a precaution, preferable to avoid. Stopping may worsen cystic fibrosis, and CF teams often continue it, so decide with the CF specialist. Breastfeeding: Safe. Low milk levels and very low infant blood levels; no infant harm reported, and expert groups consider it probably safe. EU label: weigh benefits. LactMed: check the infant's liver tests and eyes (cataracts) periodically, and test for CF, as it can mask it.
What does Ivacaftor interact with?
MediHelp lists 119 known interactions for Ivacaftor. Contraindicated: 1 · Major: 10 · Moderate: 51 · Minor: 57. The most serious include Ensitrelvir, Apalutamide, Carbamazepine.
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