藥物交互作用
Ivacaftor + Phenobarbitone
嚴重程度: 嚴重
Ivacaftor and Phenobarbitone: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Phenobarbital induces CYP3A and is expected to substantially lower ivacaftor exposure, risking loss of CFTR potentiation.
用白話說明這項交互作用的意義
Ivacaftor and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivacaftor belongs to Miscellaneous; Phenobarbitone belongs to Central Nervous System.
為什麼會發生
CYP3A induction by phenobarbital accelerates ivacaftor clearance.
處置方式
Avoid coadministration; select a non-inducing anticonvulsant where possible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ivacaftor 的其他交互作用
Phenobarbitone 的其他交互作用
常見問題
Can I take Ivacaftor with Phenobarbitone?
MediHelp rates the interaction as major. Ivacaftor and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenobarbital induces CYP3A and is expected to substantially lower ivacaftor exposure, risking loss of CFTR potentiation.
How serious is the interaction between Ivacaftor and Phenobarbitone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; select a non-inducing anticonvulsant where possible.
What other medicines interact with Ivacaftor?
MediHelp also lists interactions of Ivacaftor with, for example, Ensitrelvir, Apalutamide, Carbamazepine. The full list is on the Ivacaftor page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
