藥物交互作用
Enzalutamide + Ivacaftor
嚴重程度: 嚴重
Enzalutamide and Ivacaftor: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Enzalutamide can substantially reduce ivacaftor exposure and may cause loss of therapeutic effect in cystic fibrosis. Strong CYP3A inducers are not recommended with ivacaftor.
用白話說明這項交互作用的意義
Enzalutamide and Ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Ivacaftor belongs to Miscellaneous.
為什麼會發生
Enzalutamide induces CYP3A4, increasing ivacaftor clearance.
處置方式
Avoid coadministration. Monitor lung function and symptoms if use is unavoidable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Enzalutamide 的其他交互作用
Ivacaftor 的其他交互作用
常見問題
Can I take Enzalutamide with Ivacaftor?
MediHelp rates the interaction as major. Enzalutamide and Ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide can substantially reduce ivacaftor exposure and may cause loss of therapeutic effect in cystic fibrosis. Strong CYP3A inducers are not recommended with ivacaftor.
How serious is the interaction between Enzalutamide and Ivacaftor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Monitor lung function and symptoms if use is unavoidable.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
