藥品參考
Liposomal doxorubicin
Liposomal doxorubicin is a medicine in the class oncology. It is used for kaposi's sarcoma.
- 藥物類別: Oncology
- 用途: kaposi's sarcoma
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重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01DB01
- 已知交互作用
- 146 (禁忌併用: 1 · 嚴重: 17 · 中度: 70 · 輕微: 58)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Anthracycline; intercalates between DNA base pairs, impairs topoisomerase II function and subsequently inhibits DNA and RNA replication. Doxorubicin is a strong chelator; doxorubicin-iron complex binds to cell membranes and DNA and produces free hydroxyl radicals that cleaves them.
成人常用劑量（仿單摘要）
Kaposi Sarcoma: 20 mg/m² IV q3Weeks
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: embryotoxic in rats and abortifacient in rabbits at low doses. Avoid in the 1st trimester; human data for doxorubicin later in pregnancy do not establish the risk, and any use needs specialist care. Use effective contraception during and for 6 months after treatment.
- 哺乳
- Unsafe Not known if the liposomal form passes into milk; conventional doxorubicin and its active metabolite reach high, persistent levels. Because of possible serious infant reactions, do not breastfeed during treatment. LactMed: breastfeeding is generally contraindicated with anthracyclines.
已通報的副作用
- Nausea
- Asthenia
- Anemia
- Neutropenia
- Thrombocytopenia
- Stomatitis
哪些人需要特別留意
- Based on animal data, can cause fetal harm when administered to pregnant women
- May include flushing, shortness of breath, facial swelling, headache, chills, back pain, tightness in the chest or throat
- Hypotension occurred in 11% of patients with solid tumors treated with liposomal doxorubicin
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (146)
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
- Ganciclovir + Liposomal doxorubicin Major
- Itraconazole + Liposomal doxorubicin Major
- Ketoconazole + Liposomal doxorubicin Major
- Levoketoconazole + Liposomal doxorubicin Major
同類別的其他藥品
常見問題
What is Liposomal doxorubicin used for?
Liposomal doxorubicin is a medicine in the class oncology. It is used for Kaposi's sarcoma, Multiple myeloma, Ovarian cancer.
What side effects have been reported with Liposomal doxorubicin?
Nausea, Asthenia, Anemia, Neutropenia, Thrombocytopenia, Stomatitis.
Can Liposomal doxorubicin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: embryotoxic in rats and abortifacient in rabbits at low doses. Avoid in the 1st trimester; human data for doxorubicin later in pregnancy do not establish the risk, and any use needs specialist care. Use effective contraception during and for 6 months after treatment. Breastfeeding: Unsafe. Not known if the liposomal form passes into milk; conventional doxorubicin and its active metabolite reach high, persistent levels. Because of possible serious infant reactions, do not breastfeed during treatment. LactMed: breastfeeding is generally contraindicated with anthracyclines.
What does Liposomal doxorubicin interact with?
MediHelp lists 146 known interactions for Liposomal doxorubicin. Contraindicated: 1 · Major: 17 · Moderate: 70 · Minor: 58. The most serious include Dengue vaccine, Belatacept, Cyclosporine.
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