藥物交互作用
Dronedarone + Liposomal doxorubicin
嚴重程度: 嚴重
Dronedarone and Liposomal doxorubicin: major interaction.
最後更新
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摘要
Dronedarone inhibits CYP3A4 and P-glycoprotein and could increase doxorubicin exposure. Both drugs can also affect cardiac function and QT, and dronedarone is hazardous in heart failure, making the combination undesirable.
用白話說明這項交互作用的意義
Dronedarone and Liposomal doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Liposomal doxorubicin belongs to Oncology.
為什麼會發生
Inhibition of CYP3A4 and P-glycoprotein by dronedarone, plus additive cardiac toxicity.
處置方式
Avoid if an alternative antiarrhythmic is available. If used together, monitor ECG, LVEF and blood counts closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Liposomal doxorubicin 的其他交互作用
Dronedarone 的其他交互作用
常見問題
Can I take Dronedarone with Liposomal doxorubicin?
MediHelp rates the interaction as major. Dronedarone and Liposomal doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone inhibits CYP3A4 and P-glycoprotein and could increase doxorubicin exposure. Both drugs can also affect cardiac function and QT, and dronedarone is hazardous in heart failure, making the combination undesirable.
How serious is the interaction between Dronedarone and Liposomal doxorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antiarrhythmic is available. If used together, monitor ECG, LVEF and blood counts closely.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
