藥品參考
Monomethyl fumarate
Monomethyl fumarate is a medicine in the class central nervous system. It is used for multiple sclerosis.
- 藥物類別: Central Nervous System
- 用途: multiple sclerosis
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
用途
作用方式
The mechanism in multiple sclerosis is unknown. MMF activates the Nrf2 pathway (response to oxidative stress) and is a nicotinic acid receptor agonist in vitro.
成人常用劑量（仿單摘要）
Relapsing forms of multiple sclerosis: starting dose 95 mg orally twice a day for 7 days, then maintenance 190 mg (two 95 mg capsules) orally twice a day.
懷孕與哺乳
- 懷孕
- Unknown Registry data for dimethyl fumarate (its prodrug) show no rise in birth defects or miscarriage; most exposures were in the 1st trimester. In animals, offspring survival, growth and behaviour were affected at clinically relevant doses. Use only if needed.
- 哺乳
- Safe No direct data, but it is the active form of dimethyl fumarate: low milk levels and data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. US label: weigh benefits. Monitor infant weight gain.
已通報的副作用
- Flushing
- Abdominal pain
- Diarrhea
- Nausea
- Vomiting
- Pruritus
禁忌症
- Known hypersensitivity to monomethyl fumarate, dimethyl fumarate, diroximel fumarate, or any excipient (reactions may include anaphylaxis or angioedema).
- Concomitant use with dimethyl fumarate or diroximel fumarate.
哪些人需要特別留意
- Anaphylaxis and angioedema can occur after the first dose or at any time; discontinue and do not restart.
- PML: withhold at the first sign or symptom suggestive of PML.
- Herpes zoster and other serious opportunistic infections: consider withholding until the infection resolves.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
同類別的其他藥品
常見問題
What is Monomethyl fumarate used for?
Monomethyl fumarate is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Monomethyl fumarate?
Flushing, Abdominal pain, Diarrhea, Nausea, Vomiting, Pruritus.
Can Monomethyl fumarate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Registry data for dimethyl fumarate (its prodrug) show no rise in birth defects or miscarriage; most exposures were in the 1st trimester. In animals, offspring survival, growth and behaviour were affected at clinically relevant doses. Use only if needed. Breastfeeding: Safe. No direct data, but it is the active form of dimethyl fumarate: low milk levels and data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. US label: weigh benefits. Monitor infant weight gain.
What does Monomethyl fumarate interact with?
MediHelp does not list a checked interaction for Monomethyl fumarate yet. Always tell your pharmacist about every medicine you take.
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