藥品參考
Mitoxantrone
Mitoxantrone is a medicine in the class central nervous system. It is used for leukemia.
- 藥物類別: Central Nervous System
- 用途: leukemia
最後更新
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重點資訊
- 藥物類別
- Central Nervous System
- 常見劑型
- 注射劑, 溶液
- 常見規格
- 20 mg, 2 mg, 20 mg/10 ml
- 已知交互作用
- 59 (禁忌併用: 1 · 嚴重: 20 · 中度: 31 · 輕微: 7)
- 商品名
- 5
- 國家與市場
- 3
用途
作用方式
Anthracenedione; DNA-reactive agent with cell cycle nonspecific cytocidal activity that intercalates into DNA resulting in cross-links and strand breaks; inhibits DNA and RNA synthesis
成人常用劑量（仿單摘要）
Secondary Progressive Multiple Sclerosis: 12 mg/m² short IV (5-15 minutes) infusion q3Months, Not to exceed lifetime cumulative dose of 140 mg/m²
懷孕與哺乳
- 懷孕
- Unsafe Cytotoxic; can harm the fetus. Women with multiple sclerosis need a negative pregnancy test before each dose and effective contraception. Avoid in pregnancy, especially the 1st trimester; cancer treatment later in pregnancy is a specialist decision.
- 哺乳
- Unsafe Passes into milk and was still found 28 days after a dose. US label: stop breastfeeding before starting treatment. LactMed: breastfeeding is considered contraindicated during antineoplastic therapy.
已通報的副作用
- Upper respiratory tract infection
- Diarrhea
- Nausea
- Alopecia
- Urinary tract infection
- Amenorrhea
哪些人需要特別留意
- Not indicated for primary progressive MS
- Avoid pregnancy
- Risk of cardiotoxicity & secondary AML
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (59)
- Adenovirus types 4 and 7 live + Mitoxantrone Contraindicated
- Axicabtagene ciloleucel + Mitoxantrone Major
- Belatacept + Mitoxantrone Major
- Brexucabtagene autoleucel + Mitoxantrone Major
- Ciltacabtagene autoleucel + Mitoxantrone Major
- Cyclosporine + Mitoxantrone Major
- Deferiprone + Mitoxantrone Major
- Etrasimod + Mitoxantrone Major
- Fingolimod + Mitoxantrone Major
- Hydroxyurea + Mitoxantrone Major
同類別的其他藥品
常見問題
What is Mitoxantrone used for?
Mitoxantrone is a medicine in the class central nervous system. It is used for Leukemia, Multiple sclerosis, Prostate cancer.
What side effects have been reported with Mitoxantrone?
Upper respiratory tract infection, Diarrhea, Nausea, Alopecia, Urinary tract infection, Amenorrhea.
Can Mitoxantrone be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Cytotoxic; can harm the fetus. Women with multiple sclerosis need a negative pregnancy test before each dose and effective contraception. Avoid in pregnancy, especially the 1st trimester; cancer treatment later in pregnancy is a specialist decision. Breastfeeding: Unsafe. Passes into milk and was still found 28 days after a dose. US label: stop breastfeeding before starting treatment. LactMed: breastfeeding is considered contraindicated during antineoplastic therapy.
What does Mitoxantrone interact with?
MediHelp lists 59 known interactions for Mitoxantrone. Contraindicated: 1 · Major: 20 · Moderate: 31 · Minor: 7. The most serious include Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept.
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