藥品參考
Dimethyl fumarate
Dimethyl fumarate is a medicine in the class central nervous system. It is used for multiple sclerosis.
- 藥物類別: Central Nervous System
- 用途: multiple sclerosis
最後更新
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
- ATC 代碼
- L04AX07
- 常見劑型
- 膠囊
- 常見規格
- 120 mg, 240 mg
- 已知交互作用
- 1 (禁忌併用: 1)
- 商品名
- 24
- 國家與市場
- 5
用途
作用方式
Exact mechanism is unknown Methyl ester of fumaric acid that elicits immunomodulatory effects Dimethyl fumarate and the metabolite (monomethyl fumarate [MMF]) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, a transcription factor encoded by the NFE2L2 gene
成人常用劑量（仿單摘要）
120 mg PO BID initially; after 7 days, increase to maintenance dose of 240 mg BID
懷孕與哺乳
- 懷孕
- Unknown Registry data (over 360 births) show no rise in birth defects or miscarriage; animal studies showed reproductive toxicity. EU label: use in pregnancy only if clearly needed. It is short-acting and is often stopped when pregnancy is planned or confirmed.
- 哺乳
- Safe Its active form (monomethyl fumarate) reaches milk in low amounts; data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. EU label: weigh breastfeeding against treatment. Monitor infant weight gain.
已通報的副作用
- Vomiting
- Diarrhea
- Nausea
- Abdominal pain
- Rash
- Pruritus
哪些人需要特別留意
- Progressive multifocal leukoencephalopathy (PML) resulting in death, in the postmarketing setting have occurred
- Do not restart therapy if anaphylaxis or angioedema occur
- Clinically significant cases of liver injury reported; onset ranged from a few days to several months after treatment initiation;
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (1)
- Dimethyl fumarate + Diroximel fumarate Contraindicated
同類別的其他藥品
常見問題
What is Dimethyl fumarate used for?
Dimethyl fumarate is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Dimethyl fumarate?
Vomiting, Diarrhea, Nausea, Abdominal pain, Rash, Pruritus.
Can Dimethyl fumarate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Registry data (over 360 births) show no rise in birth defects or miscarriage; animal studies showed reproductive toxicity. EU label: use in pregnancy only if clearly needed. It is short-acting and is often stopped when pregnancy is planned or confirmed. Breastfeeding: Safe. Its active form (monomethyl fumarate) reaches milk in low amounts; data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. EU label: weigh breastfeeding against treatment. Monitor infant weight gain.
What does Dimethyl fumarate interact with?
MediHelp lists 1 known interactions for Dimethyl fumarate. Contraindicated: 1. The most serious include Diroximel fumarate.
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