藥品參考
Palovarotene
Palovarotene is a medicine in the class miscellaneous. It is used for heterotopic ossification.
- 藥物類別: Miscellaneous
- 用途: heterotopic ossification
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- 常見劑型
- 膠囊
- 已知交互作用
- 47 (禁忌併用: 2 · 嚴重: 34 · 中度: 7 · 輕微: 4)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Retinoic acid receptor agonist with selectivity for the gamma subtype (RARγ). Binding to RARγ decreases BMP/ALK2 downstream signaling by inhibiting SMAD1/5/8 phosphorylation, which reduces endochondral bone formation.
成人常用劑量（仿單摘要）
FOP, adults and patients 14 years and older, daily dose: 5 mg orally once daily with food. Stop daily dosing when flare-up dosing begins.
懷孕與哺乳
- 懷孕
- Unsafe Contraindicated in pregnancy; can cause fetal harm. Retinoid-type malformations were seen in rats. No human data are available.
- 哺乳
- Unsafe No data on presence in milk. Breastfeeding is not recommended during treatment and for at least 1 month after the final dose.
已通報的副作用
- Dry skin
- Dry lips
- Arthralgia
- Pruritus
- Pain in extremity
- Rash
黑框警語
- Embryo-fetal toxicity: contraindicated in pregnancy and may cause fetal harm. Give only if conditions for pregnancy prevention are met.
禁忌症
- Pregnancy.
- History of allergy or hypersensitivity to retinoids or any component of SOHONOS.
哪些人需要特別留意
- Embryo-fetal toxicity: verify non-pregnancy before, during and 1 month after treatment; use effective contraception; do not donate blood during therapy and for 1 week after.
- Irreversible premature epiphyseal closure in growing children; assess baseline skeletal maturity and monitor every 6 to 12 months.
- Mucocutaneous reactions occurred in 98% of patients and may increase the risk of skin and soft tissue infections; photosensitivity may occur.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (47)
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
- Carbamazepine + Palovarotene Major
- Chloramphenicol + Palovarotene Major
- Clarithromycin + Palovarotene Major
- Crizotinib + Palovarotene Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Palovarotene 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
常見問題
What is Palovarotene used for?
Palovarotene is a medicine in the class miscellaneous. It is used for Heterotopic ossification.
What side effects have been reported with Palovarotene?
Dry skin, Dry lips, Arthralgia, Pruritus, Pain in extremity, Rash. Serious warning: Embryo-fetal toxicity: contraindicated in pregnancy and may cause fetal harm.
Can Palovarotene be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy; can cause fetal harm. Retinoid-type malformations were seen in rats. No human data are available. Breastfeeding: Unsafe. No data on presence in milk. Breastfeeding is not recommended during treatment and for at least 1 month after the final dose.
What does Palovarotene interact with?
MediHelp lists 47 known interactions for Palovarotene. Contraindicated: 2 · Major: 34 · Moderate: 7 · Minor: 4. The most serious include Acitretin, Isotretinoin, Amiodarone.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
