藥物交互作用
Amiodarone + Palovarotene
嚴重程度: 嚴重
Amiodarone and Palovarotene: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Amiodarone may increase palovarotene exposure, which raises the risk of retinoid toxicity such as mucocutaneous effects, bone changes and premature epiphyseal closure in growing patients.
用白話說明這項交互作用的意義
Amiodarone and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Palovarotene belongs to Miscellaneous.
為什麼會發生
Inhibition of CYP3A4 metabolism of palovarotene by amiodarone.
處置方式
Avoid the combination where possible; if unavoidable, reduce the palovarotene dose by 50% per labeling and monitor for retinoid toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amiodarone 的其他交互作用
Palovarotene 的其他交互作用
常見問題
Can I take Amiodarone with Palovarotene?
MediHelp rates the interaction as major. Amiodarone and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone may increase palovarotene exposure, which raises the risk of retinoid toxicity such as mucocutaneous effects, bone changes and premature epiphyseal closure in growing patients.
How serious is the interaction between Amiodarone and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, reduce the palovarotene dose by 50% per labeling and monitor for retinoid toxicity.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
