藥物交互作用
Isotretinoin + Palovarotene
嚴重程度: 禁忌併用
Isotretinoin and Palovarotene: contraindicated interaction.
最後更新
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摘要
Palovarotene is an oral retinoid, and adding isotretinoin produces additive retinoid exposure. This may cause hypervitaminosis A-type toxicity including mucocutaneous effects, hepatotoxicity, and raised intracranial pressure, along with additive teratogenicity.
用白話說明這項交互作用的意義
Isotretinoin and Palovarotene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isotretinoin belongs to Dermatology; Palovarotene belongs to Miscellaneous.
為什麼會發生
Additive pharmacodynamic retinoid receptor activity leading to hypervitaminosis A toxicity.
處置方式
Do not combine two systemic retinoids; use only one. Select an alternative for the second indication.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Isotretinoin 的其他交互作用
Palovarotene 的其他交互作用
常見問題
Can I take Isotretinoin with Palovarotene?
MediHelp rates the interaction as contraindicated. Isotretinoin and Palovarotene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Palovarotene is an oral retinoid, and adding isotretinoin produces additive retinoid exposure. This may cause hypervitaminosis A-type toxicity including mucocutaneous effects, hepatotoxicity, and raised intracranial pressure, along with additive teratogenicity.
How serious is the interaction between Isotretinoin and Palovarotene?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine two systemic retinoids; use only one. Select an alternative for the second indication.
What other medicines interact with Isotretinoin?
MediHelp also lists interactions of Isotretinoin with, for example, Demeclocycline, Minocycline, Oxytetracycline. The full list is on the Isotretinoin page.
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