藥品參考
Sodium phenylbutyrate
Sodium phenylbutyrate is a medicine in the class miscellaneous.
- 藥物類別: Miscellaneous
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- ATC 代碼
- A16AX03
- 常見劑型
- 錠劑, 粉劑
- 常見規格
- 483 mg/g
- 已知交互作用
- 3 (嚴重: 1 · 中度: 2)
- 商品名
- 4
- 國家與市場
- 2
作用方式
Prodrug metabolized to phenylacetate, which conjugates with glutamine to form phenylacetylglutamine; this is excreted by the kidneys, providing an alternate route for waste nitrogen excretion.
成人常用劑量（仿單摘要）
Urea cycle disorders, patients weighing 20 kg or more: 9.9 - 13 g/m2/day of sodium phenylbutyrate orally in three to six divided doses with food; maximum 20 grams per day
懷孕與哺乳
- 懷孕
- Unsafe No human data. In rats, prenatal exposure to its active metabolite phenylacetate damaged developing brain cells. Untreated urea cycle disorders are dangerous; specialist care is essential. EU label: contraindicated in pregnancy, with effective contraception; US label: use only if clearly needed.
- 哺乳
- Unknown Not known if it passes into milk. EU label: contraindicated while breastfeeding (brain damage in rat pups given phenylacetate). LactMed: highly protein bound, unlikely in important amounts; not a reason to stop, but use with caution with a newborn and watch for sedation or vomiting.
已通報的副作用
- Amenorrhea or menstrual dysfunction
- Decreased appetite
- Body odor
- Bad taste or taste aversion
哪些人需要特別留意
- Neurotoxicity from phenylacetate; consider dose reduction if symptoms are present.
- Hypokalemia: urinary potassium loss; monitor serum potassium.
- Sodium content may cause edema; discontinue if new or worsening edema occurs.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (3)
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Sodium phenylbutyrate 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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常見問題
What is Sodium phenylbutyrate used for?
Sodium phenylbutyrate is a medicine in the class miscellaneous.
What side effects have been reported with Sodium phenylbutyrate?
Amenorrhea or menstrual dysfunction, Decreased appetite, Body odor, Bad taste or taste aversion.
Can Sodium phenylbutyrate be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data. In rats, prenatal exposure to its active metabolite phenylacetate damaged developing brain cells. Untreated urea cycle disorders are dangerous; specialist care is essential. EU label: contraindicated in pregnancy, with effective contraception; US label: use only if clearly needed. Breastfeeding: Unknown. Not known if it passes into milk. EU label: contraindicated while breastfeeding (brain damage in rat pups given phenylacetate). LactMed: highly protein bound, unlikely in important amounts; not a reason to stop, but use with caution with a newborn and watch for sedation or vomiting.
What does Sodium phenylbutyrate interact with?
MediHelp lists 3 known interactions for Sodium phenylbutyrate. Major: 1 · Moderate: 2. The most serious include Sodium valproate, Haloperidol, Probenecid.
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