藥物交互作用
Probenecid + Sodium phenylbutyrate
嚴重程度: 中度
Probenecid and Sodium phenylbutyrate: moderate interaction.
最後更新
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摘要
Probenecid reduces renal excretion of phenylbutyrate metabolites, including phenylacetate and phenylacetylglutamine. Accumulation may increase adverse effects such as neurotoxicity and affect ammonia control.
用白話說明這項交互作用的意義
Probenecid and Sodium phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Probenecid belongs to Genitourinary; Sodium phenylbutyrate belongs to Miscellaneous.
為什麼會發生
Probenecid inhibits renal tubular secretion of phenylbutyrate and its conjugated metabolites via organic anion transporters.
處置方式
Monitor plasma ammonia and for neurological adverse effects; adjust the phenylbutyrate dose if signs of toxicity appear.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Probenecid 的其他交互作用
Sodium phenylbutyrate 的其他交互作用
常見問題
Can I take Probenecid with Sodium phenylbutyrate?
MediHelp rates the interaction as moderate. Probenecid and Sodium phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces renal excretion of phenylbutyrate metabolites, including phenylacetate and phenylacetylglutamine. Accumulation may increase adverse effects such as neurotoxicity and affect ammonia control.
How serious is the interaction between Probenecid and Sodium phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia and for neurological adverse effects; adjust the phenylbutyrate dose if signs of toxicity appear.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
