藥品參考
Sodium valproate
Sodium valproate is a medicine in the class central nervous system. It is used for epilepsy.
- 藥物類別: Central Nervous System
- 用途: epilepsy
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
- 又稱
- Valproate, Valproic acid
- 常見劑型
- 錠劑, 糖漿, 溶液, 膠囊, 滴劑
- 常見規格
- 200 mg, 500 mg, 200 mg/ml
- 已知交互作用
- 9 (嚴重: 5 · 中度: 4)
- 商品名
- 39
- 國家與市場
- 4
用途
作用方式
Sodium valproate has a broad spectrum of anticonvulsant activity, but is structurally unrelated to conventional antiepileptic drugs. Its proposed mode of action is mediated through effects on the function of brain gamma-aminobutyric acid (GABA).
成人常用劑量（仿單摘要）
400-800mg depending on body weight (up to 10mg/kg) followed by continuous or repeated infusion up to a maximum of 2500mg/day.
懷孕與哺乳
- 懷孕
- Unsafe Major birth-defect risk (about 1 in 10, incl. neural tube defects) and neurodevelopmental problems in up to 30-40% of exposed children. Contraindicated unless no alternative for epilepsy; never for migraine or (EU) bipolar. Specialist review; pregnancy prevention programme.
- 哺乳
- Safe Low levels in milk; usually acceptable. Watch the infant for jaundice, unusual bruising or bleeding; rare cases of low platelets reported.
已通報的副作用
- Vomiting
- Nausea
- Liver injury
- Stomatitis
- Pancreatitis
哪些人需要特別留意
- Pancreatitis, which may be severe and result in fatalities, has been very rarely reported. Patients experiencing nausea, vomiting or acute abdominal pain.
- Patients are advised not to stop valproate medication and to immediately contact a specialist in case of planned or suspected pregnancy.
- Suicidal ideation and behaviour have been reported in patients treated with anti-epileptic agents in several indications.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (9)
- Cannabidiol + Sodium valproate Major
- Fosphenytoin + Sodium valproate Major
- Glycerol phenylbutyrate + Sodium valproate Major
- Sodium phenylbutyrate + Sodium valproate Major
- Sodium valproate + Vorinostat Major
- Ganaxolone + Sodium valproate Moderate
- Rufinamide + Sodium valproate Moderate
- Sapropterin + Sodium valproate Moderate
- Sodium valproate + Telotristat etiprate Moderate
同類別的其他藥品
常見問題
What is Sodium valproate used for?
Sodium valproate is a medicine in the class central nervous system. It is used for Epilepsy.
What side effects have been reported with Sodium valproate?
Vomiting, Nausea, Liver injury, Stomatitis, Pancreatitis.
Can Sodium valproate be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Major birth-defect risk (about 1 in 10, incl. neural tube defects) and neurodevelopmental problems in up to 30-40% of exposed children. Contraindicated unless no alternative for epilepsy; never for migraine or (EU) bipolar. Specialist review; pregnancy prevention programme. Breastfeeding: Safe. Low levels in milk; usually acceptable. Watch the infant for jaundice, unusual bruising or bleeding; rare cases of low platelets reported.
What does Sodium valproate interact with?
MediHelp lists 9 known interactions for Sodium valproate. Major: 5 · Moderate: 4. The most serious include Cannabidiol, Fosphenytoin, Glycerol phenylbutyrate.
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