藥物交互作用
Cannabidiol + Sodium valproate
嚴重程度: 嚴重
Cannabidiol and Sodium valproate: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Concurrent use increases the incidence of raised liver transaminases compared with either drug alone. Cases of significant hepatotoxicity may occur.
用白話說明這項交互作用的意義
Cannabidiol and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cannabidiol belongs to Central Nervous System; Sodium valproate belongs to Central Nervous System.
為什麼會發生
Probably additive hepatotoxicity; the exact mechanism is not established.
處置方式
Check liver enzymes and bilirubin before treatment and periodically thereafter. Reduce or stop one or both drugs if transaminases rise significantly.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cannabidiol 的其他交互作用
Sodium valproate 的其他交互作用
常見問題
Can I take Cannabidiol with Sodium valproate?
MediHelp rates the interaction as major. Cannabidiol and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use increases the incidence of raised liver transaminases compared with either drug alone. Cases of significant hepatotoxicity may occur.
How serious is the interaction between Cannabidiol and Sodium valproate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before treatment and periodically thereafter. Reduce or stop one or both drugs if transaminases rise significantly.
What other medicines interact with Cannabidiol?
MediHelp also lists interactions of Cannabidiol with, for example, Phenytoin, Tacrolimus, Abiraterone. The full list is on the Cannabidiol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
