藥物交互作用
Sodium valproate + Telotristat etiprate
嚴重程度: 中度
Sodium valproate and Telotristat etiprate: moderate interaction.
最後更新
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摘要
Telotristat may reduce exposure to CYP2B6 substrates, and valproate is listed among them. This could lessen valproate efficacy, although the clinical relevance is uncertain.
用白話說明這項交互作用的意義
Sodium valproate and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sodium valproate belongs to Central Nervous System; Telotristat etiprate belongs to Gastrointestinal Tract.
為什麼會發生
Telotristat appears to induce CYP2B6, increasing metabolism of substrates.
處置方式
Monitor seizure or mood control and consider checking valproate serum levels when telotristat is started or stopped.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Telotristat etiprate 的其他交互作用
Sodium valproate 的其他交互作用
常見問題
Can I take Sodium valproate with Telotristat etiprate?
MediHelp rates the interaction as moderate. Sodium valproate and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat may reduce exposure to CYP2B6 substrates, and valproate is listed among them. This could lessen valproate efficacy, although the clinical relevance is uncertain.
How serious is the interaction between Sodium valproate and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure or mood control and consider checking valproate serum levels when telotristat is started or stopped.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
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