藥品參考
Teduglutide
Teduglutide is a medicine in the class endocrine. It is used for short-bowel syndrome.
- 藥物類別: Endocrine
- 用途: short-bowel syndrome
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Endocrine
- ATC 代碼
- A16AX08
- 常見劑型
- 注射劑
- 常見規格
- 5 mg/.5 ml
- 已知交互作用
- 32 (中度: 22 · 輕微: 10)
- 商品名
- 3
- 國家與市場
- 2
用途
作用方式
Teduglutide is an analog of human GLP-2. It binds GLP-2 receptors on intestinal enteroendocrine cells, subepithelial myofibroblasts and enteric neurons, causing local release of IGF-1, nitric oxide and keratinocyte growth factor.
成人常用劑量（仿單摘要）
Short bowel syndrome dependent on parenteral support: 0.05 mg/kg once daily, subcutaneous injection only; not for intravenous or intramuscular use
懷孕與哺乳
- 懷孕
- Unknown Limited case reports show no drug-associated risk of major birth defects or adverse outcomes; no embryo-fetal effects in rats and rabbits.
- 哺乳
- Unsafe No human milk data; teduglutide is present in rat milk. Breastfeeding is not recommended during treatment because of potential serious adverse reactions including tumorigenicity.
已通報的副作用
- Abdominal pain
- Nausea
- Upper respiratory tract infection
- Abdominal distension
- Injection site reaction
- Vomiting
哪些人需要特別留意
- Acceleration of neoplastic growth: potential for hyperplasia and neoplasia; polyps reported. Discontinue if GI malignancy develops. Colonoscopy and endoscopy needed before and during treatment.
- Intestinal obstruction has been reported; temporarily discontinue if it develops.
- Biliary and pancreatic disease (cholecystitis, cholangitis, cholelithiasis, pancreatitis): monitor bilirubin, alkaline phosphatase, lipase and amylase every 6 months.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (32)
- Chlordiazepoxide + Teduglutide Moderate
- Clonazepam + Teduglutide Moderate
- Colchicine + Teduglutide Moderate
- Cyclosporin + Teduglutide Moderate
- Digoxin + Teduglutide Moderate
- Ethosuximide + Teduglutide Moderate
- Flecainide + Teduglutide Moderate
- Fluphenazine + Teduglutide Moderate
- Haloperidol + Teduglutide Moderate
- Levothyroxine + Teduglutide Moderate
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Teduglutide 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Teduglutide used for?
Teduglutide is a medicine in the class endocrine. It is used for Short-bowel syndrome.
What side effects have been reported with Teduglutide?
Abdominal pain, Nausea, Upper respiratory tract infection, Abdominal distension, Injection site reaction, Vomiting.
Can Teduglutide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited case reports show no drug-associated risk of major birth defects or adverse outcomes; no embryo-fetal effects in rats and rabbits. Breastfeeding: Unsafe. No human milk data; teduglutide is present in rat milk. Breastfeeding is not recommended during treatment because of potential serious adverse reactions including tumorigenicity.
What does Teduglutide interact with?
MediHelp lists 32 known interactions for Teduglutide. Moderate: 22 · Minor: 10. The most serious include Chlordiazepoxide, Clonazepam, Colchicine.
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