藥品參考
Vorinostat
Vorinostat is a medicine in the class oncology. It is used for lymphoma.
- 藥物類別: Oncology
- 用途: lymphoma
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- 常見劑型
- 膠囊
- 常見規格
- 100 mg
- 已知交互作用
- 109 (禁忌併用: 1 · 嚴重: 32 · 中度: 74 · 輕微: 2)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Inhibits histone deacetylases HDAC1, HDAC2, HDAC3 (Class I) and HDAC6 (Class II), causing accumulation of acetylated histones, open chromatin and transcriptional activation, and in vitro cell cycle arrest and/or apoptosis of some transformed cells.
成人常用劑量（仿單摘要）
Cutaneous T-cell lymphoma (cutaneous manifestations, after two systemic therapies): 400 mg orally once daily with food; continue as long as no progressive disease or unacceptable toxicity
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: an HDAC inhibitor that crosses the placenta; in rats and rabbits it harmed development at about half the human exposure. Avoid; pregnancy test within 7 days before starting; contraception during and for 6 months after (men with female partners: 3 months).
- 哺乳
- Unsafe No data on passage into milk or infant effects. No LactMed record. Because of possible serious reactions in the infant, do not breastfeed during treatment and for at least 1 week after the last dose.
已通報的副作用
- Diarrhea
- Fatigue
- Nausea
- Dysgeusia
- Thrombocytopenia
- Anorexia
哪些人需要特別留意
- Thromboembolism: pulmonary embolism occurred in 5% (4/86) and DVT reported; monitor for signs and symptoms.
- Myelosuppression: dose-related thrombocytopenia and anemia; monitor blood counts every 2 weeks for the first 2 months, then monthly.
- Gastrointestinal toxicity: nausea, vomiting, diarrhea may need antiemetics, antidiarrheals and fluid/electrolyte replacement; control pre-existing symptoms before starting.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (109)
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
- Clarithromycin + Vorinostat Major
- Clozapine + Vorinostat Major
- Deferiprone + Vorinostat Major
- Dronedarone + Vorinostat Major
同類別的其他藥品
常見問題
What is Vorinostat used for?
Vorinostat is a medicine in the class oncology. It is used for Lymphoma.
What side effects have been reported with Vorinostat?
Diarrhea, Fatigue, Nausea, Dysgeusia, Thrombocytopenia, Anorexia.
Can Vorinostat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: an HDAC inhibitor that crosses the placenta; in rats and rabbits it harmed development at about half the human exposure. Avoid; pregnancy test within 7 days before starting; contraception during and for 6 months after (men with female partners: 3 months). Breastfeeding: Unsafe. No data on passage into milk or infant effects. No LactMed record. Because of possible serious reactions in the infant, do not breastfeed during treatment and for at least 1 week after the last dose.
What does Vorinostat interact with?
MediHelp lists 109 known interactions for Vorinostat. Contraindicated: 1 · Major: 32 · Moderate: 74 · Minor: 2. The most serious include Thioridazine, Amiodarone, Amisulpride.
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