藥物交互作用
Anagrelide + Vorinostat
嚴重程度: 嚴重
Anagrelide and Vorinostat: major interaction.
最後更新
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摘要
Both drugs have been associated with QT interval prolongation, so combined use may increase the chance of torsades de pointes and other ventricular arrhythmias. Patients with cardiac disease or electrolyte abnormalities are at greatest risk.
用白話說明這項交互作用的意義
Anagrelide and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Vorinostat belongs to Oncology.
為什麼會發生
Additive pharmacodynamic prolongation of cardiac repolarization.
處置方式
Prefer an alternative to one of the agents. If both are required, check a baseline ECG, correct potassium and magnesium, and repeat ECGs periodically.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Anagrelide 的其他交互作用
Vorinostat 的其他交互作用
常見問題
Can I take Anagrelide with Vorinostat?
MediHelp rates the interaction as major. Anagrelide and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have been associated with QT interval prolongation, so combined use may increase the chance of torsades de pointes and other ventricular arrhythmias. Patients with cardiac disease or electrolyte abnormalities are at greatest risk.
How serious is the interaction between Anagrelide and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to one of the agents. If both are required, check a baseline ECG, correct potassium and magnesium, and repeat ECGs periodically.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
