藥物交互作用
Clozapine + Vorinostat
嚴重程度: 嚴重
Clozapine and Vorinostat: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Vorinostat has been associated with QT prolongation, and clozapine can have the same effect. Concurrent use may increase the risk of serious ventricular arrhythmias.
用白話說明這項交互作用的意義
Clozapine and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Vorinostat belongs to Oncology.
為什麼會發生
Additive pharmacodynamic QT prolongation.
處置方式
Avoid the combination if an alternative exists. If it is necessary, monitor ECG and keep potassium and magnesium within normal range.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clozapine 的其他交互作用
Vorinostat 的其他交互作用
常見問題
Can I take Clozapine with Vorinostat?
MediHelp rates the interaction as major. Clozapine and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorinostat has been associated with QT prolongation, and clozapine can have the same effect. Concurrent use may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Clozapine and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is necessary, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
