藥物交互作用
Acalabrutinib + Dexlansoprazole
嚴重程度: 嚴重
Acalabrutinib and Dexlansoprazole: major interaction.
最後更新
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摘要
Acalabrutinib capsules need an acidic stomach to dissolve, and dexlansoprazole raises gastric pH for a prolonged period. This can substantially reduce acalabrutinib absorption and may reduce efficacy.
用白話說明這項交互作用的意義
Acalabrutinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acalabrutinib belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
為什麼會發生
PPI-induced rise in gastric pH reduces acalabrutinib capsule solubility and absorption.
處置方式
Avoid the PPI where possible; use an antacid 2 hours apart or an H2 blocker 2 hours after acalabrutinib. The tablet formulation can be used if a PPI is required.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexlansoprazole 的其他交互作用
Acalabrutinib 的其他交互作用
常見問題
Can I take Acalabrutinib with Dexlansoprazole?
MediHelp rates the interaction as major. Acalabrutinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acalabrutinib capsules need an acidic stomach to dissolve, and dexlansoprazole raises gastric pH for a prolonged period. This can substantially reduce acalabrutinib absorption and may reduce efficacy.
How serious is the interaction between Acalabrutinib and Dexlansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the PPI where possible; use an antacid 2 hours apart or an H2 blocker 2 hours after acalabrutinib. The tablet formulation can be used if a PPI is required.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Atazanavir. The full list is on the Dexlansoprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
