藥物交互作用
Dasatinib + Dexlansoprazole
嚴重程度: 嚴重
Dasatinib and Dexlansoprazole: major interaction.
最後更新
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摘要
Dasatinib absorption depends on acidic gastric pH, so PPIs reduce its exposure and may compromise leukemia control.
用白話說明這項交互作用的意義
Dasatinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
為什麼會發生
Raised gastric pH reduces dasatinib dissolution and absorption.
處置方式
Avoid PPIs with dasatinib. Use a short-acting antacid at least 2 hours apart from dasatinib if acid suppression is needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexlansoprazole 的其他交互作用
Dasatinib 的其他交互作用
常見問題
Can I take Dasatinib with Dexlansoprazole?
MediHelp rates the interaction as major. Dasatinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib absorption depends on acidic gastric pH, so PPIs reduce its exposure and may compromise leukemia control.
How serious is the interaction between Dasatinib and Dexlansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dasatinib. Use a short-acting antacid at least 2 hours apart from dasatinib if acid suppression is needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
