藥物交互作用
Acalabrutinib + Omeprazole
嚴重程度: 嚴重
Acalabrutinib and Omeprazole: major interaction.
最後更新
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摘要
Acalabrutinib capsules dissolve poorly at higher gastric pH, so omeprazole can reduce its absorption and exposure. This may lower efficacy in patients with B-cell malignancies.
用白話說明這項交互作用的意義
Acalabrutinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acalabrutinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
為什麼會發生
PPI-induced rise in gastric pH reduces acalabrutinib solubility and absorption.
處置方式
Avoid the PPI where possible, and consider an antacid or H2 blocker with appropriate timing instead. The tablet formulation is not affected by gastric pH.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Omeprazole 的其他交互作用
Acalabrutinib 的其他交互作用
常見問題
Can I take Acalabrutinib with Omeprazole?
MediHelp rates the interaction as major. Acalabrutinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acalabrutinib capsules dissolve poorly at higher gastric pH, so omeprazole can reduce its absorption and exposure. This may lower efficacy in patients with B-cell malignancies.
How serious is the interaction between Acalabrutinib and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the PPI where possible, and consider an antacid or H2 blocker with appropriate timing instead. The tablet formulation is not affected by gastric pH.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Atazanavir. The full list is on the Omeprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
