藥物交互作用
Mavacamten + Omeprazole
嚴重程度: 禁忌併用
Mavacamten and Omeprazole: contraindicated interaction.
最後更新
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摘要
Omeprazole inhibits CYP2C19 and can raise mavacamten exposure. Excess mavacamten can reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction.
用白話說明這項交互作用的意義
Mavacamten and Omeprazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mavacamten belongs to Cardiovascular; Omeprazole belongs to Gastrointestinal Tract.
為什麼會發生
Inhibition of CYP2C19-mediated metabolism of mavacamten increases its plasma concentrations.
處置方式
Avoid the combination; use an acid suppressant without CYP2C19 inhibition (e.g., an H2 blocker, or per labeling) if required. If started or stopped, follow label guidance with echocardiographic monitoring of ejection fraction.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Omeprazole 的其他交互作用
Mavacamten 的其他交互作用
常見問題
Can I take Mavacamten with Omeprazole?
MediHelp rates the interaction as contraindicated. Mavacamten and Omeprazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Omeprazole inhibits CYP2C19 and can raise mavacamten exposure. Excess mavacamten can reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction.
How serious is the interaction between Mavacamten and Omeprazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an acid suppressant without CYP2C19 inhibition (e.g., an H2 blocker, or per labeling) if required. If started or stopped, follow label guidance with echocardiographic monitoring of ejection fraction.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Omeprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
