藥物交互作用
Acalabrutinib + Rabeprazole
嚴重程度: 嚴重
Acalabrutinib and Rabeprazole: major interaction.
最後更新
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摘要
Acalabrutinib capsules dissolve poorly at higher gastric pH, so PPIs lower exposure and may reduce efficacy. PPI effect is long lasting, so dose separation does not resolve it.
用白話說明這項交互作用的意義
Acalabrutinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acalabrutinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
為什麼會發生
Increased gastric pH reduces acalabrutinib solubility and absorption.
處置方式
Avoid rabeprazole. Use an antacid or H2 antagonist with appropriate timing, or switch to the acalabrutinib tablet formulation, which is not affected by pH.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rabeprazole 的其他交互作用
Acalabrutinib 的其他交互作用
常見問題
Can I take Acalabrutinib with Rabeprazole?
MediHelp rates the interaction as major. Acalabrutinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acalabrutinib capsules dissolve poorly at higher gastric pH, so PPIs lower exposure and may reduce efficacy. PPI effect is long lasting, so dose separation does not resolve it.
How serious is the interaction between Acalabrutinib and Rabeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rabeprazole. Use an antacid or H2 antagonist with appropriate timing, or switch to the acalabrutinib tablet formulation, which is not affected by pH.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Atazanavir, Dacomitinib. The full list is on the Rabeprazole page.
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