藥物交互作用
Gefitinib + Rabeprazole
嚴重程度: 嚴重
Gefitinib and Rabeprazole: major interaction.
最後更新
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摘要
Rabeprazole raises gastric pH, and gefitinib solubility falls sharply at higher pH. Gefitinib exposure can drop substantially, which may reduce antitumor efficacy.
用白話說明這項交互作用的意義
Gefitinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
為什麼會發生
Higher gastric pH reduces gefitinib solubility and absorption.
處置方式
Avoid the PPI if possible and use short-acting antacids or H2 blockers with dosing separated from gefitinib as per labeling. If a PPI is essential, take gefitinib 12 hours after the PPI dose and monitor tumor response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rabeprazole 的其他交互作用
Gefitinib 的其他交互作用
常見問題
Can I take Gefitinib with Rabeprazole?
MediHelp rates the interaction as major. Gefitinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rabeprazole raises gastric pH, and gefitinib solubility falls sharply at higher pH. Gefitinib exposure can drop substantially, which may reduce antitumor efficacy.
How serious is the interaction between Gefitinib and Rabeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the PPI if possible and use short-acting antacids or H2 blockers with dosing separated from gefitinib as per labeling. If a PPI is essential, take gefitinib 12 hours after the PPI dose and monitor tumor response.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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