藥物交互作用
Dacomitinib + Rabeprazole
嚴重程度: 嚴重
Dacomitinib and Rabeprazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
PPIs lower dacomitinib exposure through reduced absorption. This may reduce efficacy in EGFR-mutated lung cancer.
用白話說明這項交互作用的意義
Dacomitinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
為什麼會發生
Increased gastric pH reduces dacomitinib solubility and absorption.
處置方式
Avoid PPIs. Use a locally acting antacid or an H2 antagonist, giving dacomitinib at least 6 hours before or 10 hours after the H2 antagonist.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rabeprazole 的其他交互作用
Dacomitinib 的其他交互作用
常見問題
Can I take Dacomitinib with Rabeprazole?
MediHelp rates the interaction as major. Dacomitinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. PPIs lower dacomitinib exposure through reduced absorption. This may reduce efficacy in EGFR-mutated lung cancer.
How serious is the interaction between Dacomitinib and Rabeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs. Use a locally acting antacid or an H2 antagonist, giving dacomitinib at least 6 hours before or 10 hours after the H2 antagonist.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
