藥物交互作用
Acalabrutinib + Sulphasalazine
嚴重程度: 中度
Acalabrutinib and Sulphasalazine: moderate interaction.
最後更新
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摘要
Acalabrutinib can inhibit intestinal BCRP, a transporter that limits sulfasalazine absorption, so sulfasalazine exposure may rise. Both drugs can also cause myelosuppression, so the effect may be additive.
用白話說明這項交互作用的意義
Acalabrutinib and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acalabrutinib belongs to Oncology; Sulphasalazine belongs to Gastrointestinal Tract.
為什麼會發生
Intestinal BCRP inhibition by acalabrutinib increases sulfasalazine absorption, plus additive bone marrow suppression.
處置方式
Monitor complete blood counts regularly during combined use and reduce sulfasalazine dose if cytopenias or adverse effects arise.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Sulphasalazine 的其他交互作用
Acalabrutinib 的其他交互作用
常見問題
Can I take Acalabrutinib with Sulphasalazine?
MediHelp rates the interaction as moderate. Acalabrutinib and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acalabrutinib can inhibit intestinal BCRP, a transporter that limits sulfasalazine absorption, so sulfasalazine exposure may rise. Both drugs can also cause myelosuppression, so the effect may be additive.
How serious is the interaction between Acalabrutinib and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly during combined use and reduce sulfasalazine dose if cytopenias or adverse effects arise.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
