藥物交互作用
Acetylsalicylic acid + Bismuth subsalicylate
嚴重程度: 中度
Acetylsalicylic acid and Bismuth subsalicylate: moderate interaction.
最後更新
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摘要
Bismuth subsalicylate is hydrolysed to release salicylate, so taking it with aspirin adds to the total salicylate load. This can raise the risk of salicylate toxicity such as tinnitus and gastrointestinal bleeding, especially with repeated or high dosing.
用白話說明這項交互作用的意義
Acetylsalicylic acid and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Bismuth subsalicylate belongs to Gastrointestinal Tract.
為什麼會發生
Additive salicylate exposure and additive antiplatelet and gastrointestinal mucosal effects.
處置方式
Avoid routine concurrent use of bismuth subsalicylate with analgesic-dose aspirin and limit duration. Monitor for tinnitus, GI bleeding and bruising, particularly in older adults and those on anticoagulants.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Acetylsalicylic acid 的其他交互作用
Bismuth subsalicylate 的其他交互作用
常見問題
Can I take Acetylsalicylic acid with Bismuth subsalicylate?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth subsalicylate is hydrolysed to release salicylate, so taking it with aspirin adds to the total salicylate load. This can raise the risk of salicylate toxicity such as tinnitus and gastrointestinal bleeding, especially with repeated or high dosing.
How serious is the interaction between Acetylsalicylic acid and Bismuth subsalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of bismuth subsalicylate with analgesic-dose aspirin and limit duration. Monitor for tinnitus, GI bleeding and bruising, particularly in older adults and those on anticoagulants.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
