藥物交互作用
Amlodipine-benazepril + Bismuth subsalicylate
嚴重程度: 中度
Amlodipine-benazepril and Bismuth subsalicylate: moderate interaction.
最後更新
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摘要
Bismuth subsalicylate releases salicylate, which can blunt the antihypertensive effect of benazepril and may add to renal risk. The effect is mainly relevant with frequent or prolonged use, or in dehydrated or renally impaired patients.
用白話說明這項交互作用的意義
Amlodipine-benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Bismuth subsalicylate belongs to Gastrointestinal Tract.
為什麼會發生
Salicylate inhibits prostaglandin synthesis, reducing renal vasodilation and sodium excretion and opposing ACE inhibitor effects.
處置方式
Limit bismuth subsalicylate to short-term use and avoid it in renal impairment or dehydration. Monitor blood pressure and renal function if use is prolonged.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-benazepril 的其他交互作用
Bismuth subsalicylate 的其他交互作用
常見問題
Can I take Amlodipine-benazepril with Bismuth subsalicylate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth subsalicylate releases salicylate, which can blunt the antihypertensive effect of benazepril and may add to renal risk. The effect is mainly relevant with frequent or prolonged use, or in dehydrated or renally impaired patients.
How serious is the interaction between Amlodipine-benazepril and Bismuth subsalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit bismuth subsalicylate to short-term use and avoid it in renal impairment or dehydration. Monitor blood pressure and renal function if use is prolonged.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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