藥物交互作用
Activated charcoal + Methotrexate
嚴重程度: 中度
Activated charcoal and Methotrexate: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Activated charcoal binds methotrexate in the gut and can interrupt its enterohepatic recirculation, lowering its levels. This reduces the effect of therapeutic doses but is used deliberately in overdose.
用白話說明這項交互作用的意義
Activated charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Activated charcoal belongs to Gastrointestinal Tract; Methotrexate belongs to Oncology.
為什麼會發生
Adsorption of methotrexate in the gastrointestinal tract reduces absorption and enterohepatic reabsorption.
處置方式
Separate charcoal from oral methotrexate doses unless it is being given for overdose. In overdose, consider repeated charcoal alongside leucovorin and supportive care.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Methotrexate 的其他交互作用
Activated charcoal 的其他交互作用
常見問題
Can I take Activated charcoal with Methotrexate?
MediHelp rates the interaction as moderate. Activated charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Activated charcoal binds methotrexate in the gut and can interrupt its enterohepatic recirculation, lowering its levels. This reduces the effect of therapeutic doses but is used deliberately in overdose.
How serious is the interaction between Activated charcoal and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate charcoal from oral methotrexate doses unless it is being given for overdose. In overdose, consider repeated charcoal alongside leucovorin and supportive care.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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