藥物交互作用
Adalimumab + Axicabtagene ciloleucel
嚴重程度: 嚴重
Adalimumab and Axicabtagene ciloleucel: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
CAR-T recipients are prone to prolonged cytopenias and infections, and adalimumab adds immunosuppression. Immunosuppressants may also blunt CAR-T expansion and efficacy.
用白話說明這項交互作用的意義
Adalimumab and Axicabtagene ciloleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Adalimumab belongs to Musculoskeletal; Axicabtagene ciloleucel belongs to Oncology.
為什麼會發生
Additive immunosuppression and possible impairment of CAR-T cell expansion.
處置方式
Avoid planned adalimumab around lymphodepletion and infusion unless essential. Monitor for infection and cytopenias if it is required.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Adalimumab 的其他交互作用
- Adalimumab + Bcg vaccine live 禁忌併用
- Adalimumab + Influenza virus vaccine quadrivalent intranasal 禁忌併用
- Adalimumab + Measles mumps and rubella vaccine 禁忌併用
- Adalimumab + Measles mumps and rubella vaccine live 禁忌併用
- Adalimumab + Measles mumps rubella and varicella vaccine live 禁忌併用
- Adalimumab + Measles vaccine 禁忌併用
Axicabtagene ciloleucel 的其他交互作用
常見問題
Can I take Adalimumab with Axicabtagene ciloleucel?
MediHelp rates the interaction as major. Adalimumab and Axicabtagene ciloleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. CAR-T recipients are prone to prolonged cytopenias and infections, and adalimumab adds immunosuppression. Immunosuppressants may also blunt CAR-T expansion and efficacy.
How serious is the interaction between Adalimumab and Axicabtagene ciloleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid planned adalimumab around lymphodepletion and infusion unless essential. Monitor for infection and cytopenias if it is required.
What other medicines interact with Adalimumab?
MediHelp also lists interactions of Adalimumab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Adalimumab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
