藥物交互作用
Axicabtagene ciloleucel + Azathioprine
嚴重程度: 嚴重
Axicabtagene ciloleucel and Azathioprine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. Concurrent immunosuppression also adds to infection risk after lymphodepletion.
用白話說明這項交互作用的意義
Axicabtagene ciloleucel and Azathioprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Azathioprine belongs to Gastrointestinal Tract.
為什麼會發生
Immunosuppressive antimetabolite activity against lymphocytes may reduce CAR-T cell expansion and persistence.
處置方式
Discontinue azathioprine before leukapheresis and infusion as advised by the treating CAR-T center. Monitor for infections if immunosuppression cannot be stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Azathioprine 的其他交互作用
Axicabtagene ciloleucel 的其他交互作用
常見問題
Can I take Axicabtagene ciloleucel with Azathioprine?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Azathioprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. Concurrent immunosuppression also adds to infection risk after lymphodepletion.
How serious is the interaction between Axicabtagene ciloleucel and Azathioprine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue azathioprine before leukapheresis and infusion as advised by the treating CAR-T center. Monitor for infections if immunosuppression cannot be stopped.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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