藥物交互作用
Axicabtagene ciloleucel + Baricitinib
嚴重程度: 嚴重
Axicabtagene ciloleucel and Baricitinib: major interaction.
最後更新
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摘要
Baricitinib may impair CAR T-cell expansion and function and adds to infection risk after lymphodepleting therapy. This may reduce the efficacy of the cell product.
用白話說明這項交互作用的意義
Axicabtagene ciloleucel and Baricitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Baricitinib belongs to Musculoskeletal.
為什麼會發生
JAK inhibition suppresses T-cell activation and proliferation, potentially blunting CAR T-cell activity.
處置方式
Avoid baricitinib around leukapheresis and CAR T infusion unless essential. Coordinate with the oncology team and monitor for infection.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Baricitinib 的其他交互作用
Axicabtagene ciloleucel 的其他交互作用
常見問題
Can I take Axicabtagene ciloleucel with Baricitinib?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Baricitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baricitinib may impair CAR T-cell expansion and function and adds to infection risk after lymphodepleting therapy. This may reduce the efficacy of the cell product.
How serious is the interaction between Axicabtagene ciloleucel and Baricitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid baricitinib around leukapheresis and CAR T infusion unless essential. Coordinate with the oncology team and monitor for infection.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
